Jump to main content
Jump to site search

Issue 31, 2008
Previous Article Next Article

Calcium phosphatenanoparticles: colloidally stabilized and made fluorescent by a phosphate-functionalized porphyrin

Author affiliations

Abstract

Calcium phosphate nanoparticles were prepared by precipitation and colloidally stabilized by surface functionalization with 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (p-TPPP). No other stabilizing agents were necessary, and all dissolved counter-ions and excess porphyrin were removed by ultracentrifugation. The resulting porphyrin-functionalized nanoparticles were spherical with a diameter of about 250 nm. The adsorption of porphyrin on the calcium phosphate surface was confirmed by IR spectroscopy and quantified by elemental analysis (the loading was about 4–5 wt% porphyrin). In a cell culture with NIH 3T3 fibroblast cells, the particles showed excellent biocompatibility (confirmed by an MTT test), and their uptake into the cells could be followed by confocal laser scanning microscopy. Hence, these biocompatible nanoparticles may be used as biocompatible fluorescing agents or for the delivery of fluorescing molecules.

Graphical abstract: Calcium phosphate nanoparticles: colloidally stabilized and made fluorescent by a phosphate-functionalized porphyrin

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Mar 2008, accepted on 19 May 2008 and first published on 25 Jun 2008


Article type: Paper
DOI: 10.1039/B805366A
J. Mater. Chem., 2008,18, 3655-3661

  •   Request permissions

    Calcium phosphate nanoparticles: colloidally stabilized and made fluorescent by a phosphate-functionalized porphyrin

    K. Ganesan, A. Kovtun, S. Neumann, R. Heumann and M. Epple, J. Mater. Chem., 2008, 18, 3655
    DOI: 10.1039/B805366A

Search articles by author

Spotlight

Advertisements