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Issue 37, 2008
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Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

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Abstract

Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.

Graphical abstract: Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

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Publication details

The article was received on 19 Mar 2008, accepted on 23 May 2008 and first published on 03 Jul 2008


Article type: Paper
DOI: 10.1039/B804544E
J. Mater. Chem., 2008,18, 4402-4407

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    Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

    S. Seo, J. Yang, E. Lee, Y. Jung, K. Kim, S. Lee, D. Kim, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2008, 18, 4402
    DOI: 10.1039/B804544E

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