Issue 8, 2008

Polymers for intracellular delivery of nucleic acids

Abstract

Effective delivery of nucleic acids requires overcoming cellular barriers that would otherwise hinder transport of payload from the extracellular space to the cytoplasm or nucleus of a target cell, and preventing the degradation of the payload. As with many drug-delivery systems, toxicity is an important issue. Rational design of polymers for this purpose, assisted by high-throughput synthesis and screening methods, has had an enormous impact on the field.

Graphical abstract: Polymers for intracellular delivery of nucleic acids

Article information

Article type
Highlight
Submitted
22 Aug 2007
Accepted
24 Oct 2007
First published
14 Nov 2007

J. Mater. Chem., 2008,18, 832-841

Polymers for intracellular delivery of nucleic acids

S. R. Little and D. S. Kohane, J. Mater. Chem., 2008, 18, 832 DOI: 10.1039/B712930K

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