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Issue 8, 2008
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Polymers for intracellular delivery of nucleic acids

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Abstract

Effective delivery of nucleic acids requires overcoming cellular barriers that would otherwise hinder transport of payload from the extracellular space to the cytoplasm or nucleus of a target cell, and preventing the degradation of the payload. As with many drug-delivery systems, toxicity is an important issue. Rational design of polymers for this purpose, assisted by high-throughput synthesis and screening methods, has had an enormous impact on the field.

Graphical abstract: Polymers for intracellular delivery of nucleic acids

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Article information


Submitted
22 Aug 2007
Accepted
24 Oct 2007
First published
14 Nov 2007

J. Mater. Chem., 2008,18, 832-841
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Polymers for intracellular delivery of nucleic acids

S. R. Little and D. S. Kohane, J. Mater. Chem., 2008, 18, 832
DOI: 10.1039/B712930K

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