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Issue 4, 2008
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Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water”

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Abstract

We have developed a quick and highly efficient method for copper-catalyzed cycloaddition of water-insoluble aliphatic/aryl azides and alkynes “on water” at room temperature, the protocol uses 10 mol% CuBr as the catalyst, and 50 mol% PhSMe as the ligand.

Graphical abstract: Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water”

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Article information


Submitted
21 Nov 2007
Accepted
16 Jan 2008
First published
25 Feb 2008

Green Chem., 2008,10, 452-456
Article type
Paper

Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water

F. Wang, H. Fu, Y. Jiang and Y. Zhao, Green Chem., 2008, 10, 452
DOI: 10.1039/B718051A

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