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Issue 5, 2008
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Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(ii) bipyridyl units linked by a bis(pyridylimine) ligand

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Abstract

Enantiopure dinuclear ruthenium polypyridyl complexes of the form [Ru2(LL)4L1](PF6)4 (LL = 2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen); L1 = C25H20N4 a bis(pyridylimine) ligand containing a diphenylmethane spacer) have been synthesized using the chiral building blocks cis-[Ru(bpy)2(py)2]2+ and cis-[Ru(phen)2(py)2]2+. These dinuclear ruthenium complexes have been characterised using NMR, mass spectrometry, UV-visible absorbance, circular dichroism and linear dichroism. The compounds exhibit good photo and thermal stability. The extinction coefficient for the bpy complex at 478 nm is ε478 = 15 700 mol−1 cm−1 dm3 and for the phen complex is ε478 = 24 900 mol−1 cm−1 dm3. Both complexes have their longest wavelength (metal to ligand charge transfer) transition predominantly x/y (short axis)-polarised while the transitions at shorter wavelength are a mixture of x/y and z-polarisations, similar to both the copper helicate and iron triple helicate studied previously. Cytotoxicity studies reveal that the compounds are dramatically less active against cancer cell lines than the recently reported supramolecular cylinders prepared from the same bis(pyridylimine) ligand.

Graphical abstract: Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(ii) bipyridyl units linked by a bis(pyridylimine) ligand

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Supplementary files

Article information


Submitted
19 Jul 2007
Accepted
19 Oct 2007
First published
21 Nov 2007

Dalton Trans., 2008, 667-675
Article type
Paper

Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(II) bipyridyl units linked by a bis(pyridylimine) ligand

U. McDonnell, J. M. C. A. Kerchoffs, R. P. M. Castineiras, M. R. Hicks, A. C. G. Hotze, M. J. Hannon and A. Rodger, Dalton Trans., 2008, 667
DOI: 10.1039/B711080D

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