Jump to main content
Jump to site search

Issue 8, 2008
Previous Article Next Article

Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

Author affiliations

Abstract

The combination of the unique physical and chemical properties of fluorine with proteinogenic amino acids represents a new approach to the design of biologically active compounds including peptides with improved pharmacological parameters. Therefore, the development of routine synthetic methods which enable the effective and selective introduction of fluorine into the desired amino acids from readily available starting materials is of significant synthetic importance. The scope of this critical review is to summarize the most frequently employed strategies for the synthesis of α-difluoromethyl and α-trifluoromethyl substituted α-amino acids (114 references).

Graphical abstract: Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

Back to tab navigation

Publication details

The article was received on 27 Mar 2008 and first published on 26 Jun 2008


Article type: Critical Review
DOI: 10.1039/B800310F
Chem. Soc. Rev., 2008,37, 1727-1739

  •   Request permissions

    Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

    R. Smits, C. D. Cadicamo, K. Burger and B. Koksch, Chem. Soc. Rev., 2008, 37, 1727
    DOI: 10.1039/B800310F

Search articles by author

Spotlight

Advertisements