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Issue 7, 2008
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Nucleic acid encoding to program self-assembly in chemical biology

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Abstract

This tutorial review serves as an introduction to the use of oligonucleotides and in particular peptide nucleic acids (PNAs) to encode function beyond heredity. Applications in chemical biology are reviewed starting with the use of nucleic acid tags to program self-assembled microarrays of small and macromolecules, followed by the use of nucleic acid templated reactions for the purpose of DNA or RNA sensing and finally, the use of nucleic acid templates to display ligands.

Graphical abstract: Nucleic acid encoding to program self-assembly in chemical biology

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Publication details

The article was received on 02 Feb 2008 and first published on 17 Apr 2008


Article type: Tutorial Review
DOI: 10.1039/B706610B
Chem. Soc. Rev., 2008,37, 1330-1336

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    Nucleic acid encoding to program self-assembly in chemical biology

    Z. L. Pianowski and N. Winssinger, Chem. Soc. Rev., 2008, 37, 1330
    DOI: 10.1039/B706610B

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