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Issue 7, 2008
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Chemical biology—identification of small molecule modulators of cellular activity by natural product inspired synthesis

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Abstract

The aim of this tutorial review is to introduce the reader to the concept, synthesis and application of natural product-inspired compound collections as an important field in chemical biology. This review will discuss how potentially interesting scaffolds can be identified (structural classification of natural products), synthesized in an appropriate manner (including stereoselective transformations for solid phase-bound compounds) and tested in biological assays (cell-based screening as well as biochemical in vitro assays). These approaches will provide the opportunity to identify new and interesting compounds as well as new targets for chemical biology and medicinal chemistry research.

Graphical abstract: Chemical biology—identification of small molecule modulators of cellular activity by natural product inspired synthesis

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Publication details

The article was received on 31 Mar 2008 and first published on 14 May 2008


Article type: Tutorial Review
DOI: 10.1039/B704729K
Chem. Soc. Rev., 2008,37, 1361-1374

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    Chemical biology—identification of small molecule modulators of cellular activity by natural product inspired synthesis

    K. Hübel, T. Leßmann and H. Waldmann, Chem. Soc. Rev., 2008, 37, 1361
    DOI: 10.1039/B704729K

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