Sophie Purser, Peter R. Moore, Steve Swallow and Véronique Gouverneur
Chem. Soc. Rev., 2008,37, 320-330
DOI:
10.1039/B610213C,
Tutorial Review
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
