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Issue 28, 2008
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Glucose, sucrose and trehalose are partially excluded from the interface of hydrated DMPC bilayers

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Abstract

The free energy of membrane–sugar interactions for DMPC bilayers hydrated in binary aqueous mixtures of, respectively, glucose, sucrose and trehalose was directly determined by differential vapor pressure measurements using both isothermal and temperature scanning modes. It was consistently found that the membrane interacts more favorably with water than with the sugars, and thus concluded that the sugars are preferentially excluded from the hydration layers. This observation contradicts a number of recent computational studies.

Graphical abstract: Glucose, sucrose and trehalose are partially excluded from the interface of hydrated DMPC bilayers

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Article information


Submitted
14 Apr 2008
Accepted
03 Jun 2008
First published
13 Jun 2008

Phys. Chem. Chem. Phys., 2008,10, 4110-4112
Article type
Communication

Glucose, sucrose and trehalose are partially excluded from the interface of hydrated DMPC bilayers

P. Westh, Phys. Chem. Chem. Phys., 2008, 10, 4110
DOI: 10.1039/B806274A

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