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Issue 43, 2008
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Flexible total synthesis of biphenomycin B

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Abstract

A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki–Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity.

Graphical abstract: Flexible total synthesis of biphenomycin B

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Publication details

The article was received on 08 Jul 2008, accepted on 01 Aug 2008 and first published on 25 Sep 2008


Article type: Communication
DOI: 10.1039/B811583D
Chem. Commun., 2008, 5562-5564

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    Flexible total synthesis of biphenomycin B

    H. Waldmann, Y. He, H. Tan, L. Arve and H. Arndt, Chem. Commun., 2008, 5562
    DOI: 10.1039/B811583D

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