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Issue 26, 2008
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G-quadruplex recognition by bis-indole carboxamides

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Abstract

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

Graphical abstract: G-quadruplex recognition by bis-indole carboxamides

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Article information


Submitted
09 Apr 2008
Accepted
29 Apr 2008
First published
05 Jun 2008

Chem. Commun., 2008, 3055-3057
Article type
Communication

G-quadruplex recognition by bis-indole carboxamides

J. Dash, P. S. Shirude and S. Balasubramanian, Chem. Commun., 2008, 3055
DOI: 10.1039/B806042H

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