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Issue 10, 2008
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Formal total synthesis of triptolide

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Abstract

A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels–Alder reactions and a new deoxygenative aromatisation process.

Graphical abstract: Formal total synthesis of triptolide

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Supplementary files

Article information


Submitted
04 Dec 2007
Accepted
09 Jan 2008
First published
30 Jan 2008

Chem. Commun., 2008, 1226-1228
Article type
Communication

Formal total synthesis of triptolide

N. A. Miller, A. C. Willis and M. S. Sherburn, Chem. Commun., 2008, 1226
DOI: 10.1039/B718754H

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