Issue 36, 2008

Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

Abstract

GDP-2-, 3-, 4- or 6-azidomannoses can be successfully prepared from the corresponding azidomannose-1-phosphates and GTP using the enzyme GDP-Mannosepyrophosphorylase (GDP-ManPP) from Salmonella enterica and may serve as useful probes for mannosyltransferase activity.

Graphical abstract: Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

Supplementary files

Article information

Article type
Communication
Submitted
25 Apr 2008
Accepted
02 Jun 2008
First published
18 Jul 2008

Chem. Commun., 2008, 4321-4323

Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

S. Marchesan and D. Macmillan, Chem. Commun., 2008, 4321 DOI: 10.1039/B807016D

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