Issue 6, 2008
From the journal:

Chemical Communications

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach†‡

Marcin Kalek,§a   Peter Benediktson,a   Birte Vesterb  and  Jesper Wengel*a  

* Corresponding authors

a The Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark
E-mail: jwe@ifk.sdu.dk
Fax: +45 6550 4385
Tel: +45 6550 2510

b The Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark

Abstract

Chemically modified nucleotide monomers were incorporated into adjacent terminal positions of two separate oligonucleotides complementary to an RNA target; all possible combinations of the catalytic units were tested, resulting in an artificial nuclease that showed high activity and catalytic turnover.

Graphical abstract: Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

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Article information

DOI
https://doi.org/10.1039/B712532A
Article type
Communication
Submitted
03 Sep 2007
Accepted
26 Nov 2007
First published
12 Dec 2007

Chem. Commun., 2008, 762-764

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Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

M. Kalek, P. Benediktson, B. Vester and J. Wengel, Chem. Commun., 2008, 762 DOI: 10.1039/B712532A

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