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Issue 6, 2008
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Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

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Abstract

Chemically modified nucleotide monomers were incorporated into adjacent terminal positions of two separate oligonucleotides complementary to an RNA target; all possible combinations of the catalytic units were tested, resulting in an artificial nuclease that showed high activity and catalytic turnover.

Graphical abstract: Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

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Supplementary files

Article information


Submitted
03 Sep 2007
Accepted
26 Nov 2007
First published
12 Dec 2007

Chem. Commun., 2008, 762-764
Article type
Communication

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

M. Kalek, P. Benediktson, B. Vester and J. Wengel, Chem. Commun., 2008, 762
DOI: 10.1039/B712532A

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