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Issue 4, 2007
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The internal structure of self-assembled peptide amphiphiles nanofibers

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The self-assembly of peptide amphiphiles (PAs) into nanofibers and their bioactivity as well as physical properties have been investigated by our laboratory over the past few years. We report here on the use of transmission infrared spectroscopy (IR) and polarization modulation-infrared reflection-absorption spectroscopy (PM-IRRAS) to characterize the internal structure of the nanofibers. Depositing nanofibers flat on surfaces, and using the surface selection rules in PM-IRRAS, we demonstrate that peptide amphiphiles form β-sheets oriented parallel to the long-axis of nanofibers that pack radially from the nanofiber core. We show also that the extent of internal order depends on the molecular architecture and peptide sequence of PAs, with branched PAs yielding nanofibers with the lowest degree of internal order. Measurements of intensity and spectral position of the alkyl bands suggest that the hydrophobic core of these nanofibers can have internal order to an extent that correlates with order in their peptidic domains. We expect that bioactivity and physical properties will be controlled by the degree of internal order in these self-assembling nanostructures.

Graphical abstract: The internal structure of self-assembled peptide amphiphiles nanofibers

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The article was received on 04 Oct 2006, accepted on 02 Jan 2007 and first published on 12 Feb 2007

Article type: Paper
DOI: 10.1039/B614426H
Soft Matter, 2007,3, 454-462

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    The internal structure of self-assembled peptide amphiphiles nanofibers

    H. Jiang, M. O. Guler and S. I. Stupp, Soft Matter, 2007, 3, 454
    DOI: 10.1039/B614426H

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