Issue 21, 2007
From the journal:

Organic & Biomolecular Chemistry

Effects of oligoDNA template length and sequence on binary self-assembly of a nucleotidebolaamphiphile

Rika Iwaura,*a   Yoshihiro Kikkawa,b   Mayumi Ohnishi-Kameyamaa  and  Toshimi Shimizu*bc  

* Corresponding authors

a National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki, Japan
E-mail: riwaura@affrc.go.jp
Fax: +81 29 838 7996
Tel: +81 29 838 7154

b Nanoarchitectonics Research Center (NARC), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan
E-mail: tshmz-shimizu@aist.go.jp
Fax: +81 29 861 4545
Tel: +81 29 861 4544

c SORST, Japan Science and Technology Agency (JST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan

Abstract

Templated self-assembly of nucleotide bolaamphiphile 1 (in which a 3′-phosphorylated thymidine moiety is connected to each end of a long oligomethylene chain) with a 10-, 20-, 30-, or 40-meric single-stranded oligoadenylic acid (2, 3, 4, or 5) led to the formation of right-handed helical nanofibers in 0.1× Tris/EDTA (TE) buffer solutions. The helical pitch increased as the length of the oligoadenylic acid template increased. DNA composed of oligoadenylic and oligocytidylic acid sequences (6, 7, and 8) also acted as templates to induce the formation of helical nanofiber structures. The diameter of the nanofibers remained constant (6–6.6 nm) irrespective of the template used. The binary self-assembly of 1 with 4 also produced higher-order, double-stranded nanofibers.

Graphical abstract: Effects of oligoDNA template length and sequence on binary self-assembly of a nucleotide bolaamphiphile

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Article information

DOI
https://doi.org/10.1039/B711687J
Article type
Paper
Submitted
31 Jul 2007
Accepted
17 Sep 2007
First published
01 Oct 2007

Org. Biomol. Chem., 2007,5, 3450-3455

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Effects of oligoDNA template length and sequence on binary self-assembly of a nucleotide bolaamphiphile

R. Iwaura, Y. Kikkawa, M. Ohnishi-Kameyama and T. Shimizu, Org. Biomol. Chem., 2007, 5, 3450 DOI: 10.1039/B711687J

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