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Issue 17, 2007
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Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

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Abstract

Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.

Graphical abstract: Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

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Publication details

The article was received on 12 Jun 2007, accepted on 12 Jun 2007 and first published on 18 Jul 2007


Article type: Communication
DOI: 10.1039/B708884C
Org. Biomol. Chem., 2007,5, 2753-2755

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    Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

    S. J. Shaw, H. G. Menzella, D. C. Myles, M. Xian and A. B. Smith III, Org. Biomol. Chem., 2007, 5, 2753
    DOI: 10.1039/B708884C

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