Issue 17, 2007

Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

Abstract

Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.

Graphical abstract: Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2007
Accepted
12 Jun 2007
First published
18 Jul 2007

Org. Biomol. Chem., 2007,5, 2753-2755

Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

S. J. Shaw, H. G. Menzella, D. C. Myles, M. Xian and A. B. Smith III, Org. Biomol. Chem., 2007, 5, 2753 DOI: 10.1039/B708884C

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