Issue 12, 2007
From the journal:

Organic & Biomolecular Chemistry

Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2′-deoxyuridines fluorometrically respond to hybridization†

Robert H. E. Hudson*a  and  Arash Ghorbani-Choghamarani‡a  

* Corresponding authors

a Department of Chemistry, The University of Western Ontario, London, Ontario, Canada
E-mail: robert.hudson@uwo.ca
Fax: +1-519-661-3022
Tel: +1-519-661-2111 ext. 86349

Abstract

Selected 5-ethynyl derivatives of 2′-deoxyuridine are shown to fluorometrically respond to hybridization and selectively base-pair to adenine whilst maintaining duplex stability.

Graphical abstract: Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2′-deoxyuridines fluorometrically respond to hybridization

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Article information

DOI
https://doi.org/10.1039/B705805E
Article type
Communication
Submitted
17 Apr 2007
Accepted
08 May 2007
First published
16 May 2007

Org. Biomol. Chem., 2007,5, 1845-1848

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Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2′-deoxyuridines fluorometrically respond to hybridization

R. H. E. Hudson and A. Ghorbani-Choghamarani, Org. Biomol. Chem., 2007, 5, 1845 DOI: 10.1039/B705805E

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