Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2007
Previous Article Next Article

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Author affiliations

Abstract

Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis.

Graphical abstract: Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Back to tab navigation

Supplementary files

Article information


Submitted
23 Mar 2007
Accepted
17 May 2007
First published
29 May 2007

Org. Biomol. Chem., 2007,5, 2138-2147
Article type
Paper

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

S. G. Davies, A. Christopher Garner, J. V. A. Ouzman, P. M. Roberts, A. D. Smith, E. J. Snow, J. E. Thomson, J. A. Tamayo and R. J. Vickers, Org. Biomol. Chem., 2007, 5, 2138
DOI: 10.1039/B704475E

Social activity

Search articles by author

Spotlight

Advertisements