Issue 12, 2007
From the journal:

Organic & Biomolecular Chemistry

Designed evolution of artificial metalloenzymes: protein catalysts made to order

Marc Creusa  and  Thomas R. Ward*b  

* Corresponding authors

a Department of Cellular and Molecular Biology, University of Neuchâtel, Rue Émile-Argand 11, C.P. 158, Neuchâtel, Switzerland
E-mail: marc.creus@unine.ch
Tel: +41 32 718 2226

b Department of Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, Neuchâtel, Switzerland
E-mail: thomas.ward@unine.ch
Tel: +41 32 718 2516

Abstract

Artificial metalloenzymes based on biotin–streptavidin technology, a “fusion” of chemistry and biology, illustrate how asymmetric catalysts can be improved and evolved using chemogenetic approaches.

Graphical abstract: Designed evolution of artificial metalloenzymes: protein catalysts made to order

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Article information

DOI
https://doi.org/10.1039/B702068F
Article type
Perspective
Submitted
08 Feb 2007
First published
27 Apr 2007

Org. Biomol. Chem., 2007,5, 1835-1844

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Designed evolution of artificial metalloenzymes: protein catalysts made to order

M. Creus and T. R. Ward, Org. Biomol. Chem., 2007, 5, 1835 DOI: 10.1039/B702068F

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