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Issue 2, 2007

Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

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Abstract

3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.

Graphical abstract: Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

Supplementary files

Article information


Submitted
26 Sep 2006
Accepted
02 Nov 2006
First published
11 Dec 2006

Org. Biomol. Chem., 2007,5, 318-323
Article type
Paper

Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

R. M. Haak, C. Tarabiono, D. B. Janssen, A. J. Minnaard, J. G. de Vries and B. L. Feringa, Org. Biomol. Chem., 2007, 5, 318 DOI: 10.1039/B613937J

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