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Issue 7, 2007
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Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

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Abstract

Homo- and hetero-bifunctional glycodendrimers ending with up to 16 fucoside and/or galactoside residues were synthesized in good yields using a convergent approach. The biologically active surface carbohydrate moieties were assembled in a single and efficient step using “click chemistry”. The relative binding and cross-linking abilities of these glycodendrimers were evaluated by turbidimetric analyses using both PA-IL and PA-IIL lectins from Pseudomonas aeruginosa. Insoluble complexes were rapidly observed from the first and second generations as well as from the mixed glycodendrimer 32. This hetero-bifunctional glycodendrimer was also evaluated with PA-IL alone and showed potent cross-linking properties. These novel heterobifunctional glycodendrimers may therefore constitute strong antiadhesin properties.

Graphical abstract: Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

  • This article is part of the themed collection: Dendrimers
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Publication details

The article was received on 26 Jan 2007, accepted on 07 Mar 2007 and first published on 21 Mar 2007


Article type: Paper
DOI: 10.1039/B701237C
Citation: New J. Chem., 2007,31, 1321-1331

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    Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

    I. Deguise, D. Lagnoux and R. Roy, New J. Chem., 2007, 31, 1321
    DOI: 10.1039/B701237C

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