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Issue 5, 2007
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Preparation of orthogonally-functionalized core Click cross-linked nanoparticles

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The preparation of well-defined core cross-linked polymeric nanoparticles is reported, utilizing multi-functional dendritic cross-linkers that allow for the effective stabilization of supramolecular polymer assemblies and the simultaneous introduction of reactive groups within the core domain. Amphiphilic diblock copolymers of poly(acrylic acid)-b-poly(styrene) (PAA-b-PS) that contained alkynyl functionality, partially incorporated throughout the hydrophobic PS block segment, were utilized as Click-readied precursors for the formation of polymer micelles. Divergently-grown dendrimers of the zero, first, second and third generations, having increasing numbers of azide terminating groups ((N3)2-[G-0], (N3)4-[G-1], (N3)8-[G-2], and (N3)16-[G-3], respectively), were investigated as cross-linkers via Click reactions with the polymer alkynyl groups to form covalent linkages throughout the micellar core domains, thus forming core cross-linked nanoparticles. All four generations of dendrimers were found to cross-link the micelle core effectively and afford robust nanostructures, whilst simultaneously introducing Click-readied functionalities throughout the hydrophobic domain, which are proposed to be readily available for further chemical modification.

Graphical abstract: Preparation of orthogonally-functionalized core Click cross-linked nanoparticles

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Publication details

The article was received on 06 Nov 2006, accepted on 28 Nov 2006 and first published on 22 Jan 2007

Article type: Paper
DOI: 10.1039/B616103K
New J. Chem., 2007,31, 718-724

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    Preparation of orthogonally-functionalized core Click cross-linked nanoparticles

    R. K. O’Reilly, M. J. Joralemon, C. J. Hawker and K. L. Wooley, New J. Chem., 2007, 31, 718
    DOI: 10.1039/B616103K

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