Issue 10, 2007
From the journal:

Lab on a Chip

Multi-reservoir device for detecting a soluble cancer biomarker†

Karen D. Daniel,a   Grace Y. Kim,b   Christophoros C. Vassiliou,c   Farzad Jalali-Yazdi,a   Robert Langerad  and  Michael J. Cima*e  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

b Harvard-MIT Health Sciences & Technology, Cambridge, MA, USA

c Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA

d Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

e Department of Materials Science & Engineering, 77 Massachusetts Ave, Room 12-011, Cambridge, MA, USA
E-mail: mjcima@mit.edu
Fax: +1-617-258-6936
Tel: +1-617-253-6877

Abstract

By combining the sensing capabilities of nanoscale magnetic relaxation switches (MRS) within multi-reservoir structures, a potentially powerful implantable multiplexed sensor has been developed. MRS are magnetic nanoparticles that decrease the transverse relaxation time (T2) of water in the presence of an analyte. The switches encased in polydimethylsiloxane (PDMS) devices with polycarbonate membranes (10 nm pores) have demonstrated in vitro sensing of the beta subunit of human chorionic gonadotrophin (hCG-β), which is elevated in testicular and ovarian cancer. Devices showed transverse relaxation time (T2) shortening by magnetic resonance imaging (MRI) when incubated in analyte solutions of 0.5 to 5 µg hCG-β mL−1. The decrease in T2 was between 9% and 27% (compared to control devices) after approximately 28 h. This prototype device is an important first step in developing an implantable sensor for detecting soluble cancer biomarkers in vivo.

Graphical abstract: Multi-reservoir device for detecting a soluble cancer biomarker

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B705143C
Article type
Paper
Submitted
04 Apr 2007
Accepted
27 Jun 2007
First published
20 Jul 2007

Lab Chip, 2007,7, 1288-1293

Permissions

Request permissions

Multi-reservoir device for detecting a soluble cancer biomarker

K. D. Daniel, G. Y. Kim, C. C. Vassiliou, F. Jalali-Yazdi, R. Langer and M. J. Cima, Lab Chip, 2007, 7, 1288 DOI: 10.1039/B705143C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements