Issue 46, 2007
From the journal:

Journal of Materials Chemistry

Aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings: fabrication and application in biosensing

Vincent K. S. Hsiao,a   John R. Waldeisen,a   Yuebing Zheng,a   Pamela F. Lloyd,b   Timothy J. Bunningb  and  Tony Jun Huang*a  

* Corresponding authors

a Department of Engineering Science and Mechanics, The Pennsylvania State University, 212 Earth Engineering Science Building, University Park, PA, USA
E-mail: junhuang@psu.edu

b Air Force Research Laboratory, Materials and Manufacturing Directorate Wright-Patterson Air Force Base, Dayton, OH, USA

Abstract

We have fabricated aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings by combining holographic interference patterning and APTES-functionalization of the pre-polymer syrup. The APTES facilitates the immobilization of biomolecules onto the polymeric grating surfaces. The successful detection of multiple biomolecules (biotin, steptavidin, biotinylated anti-rabbit IgG, and rabbit-IgG) indicates that the functionalized nanoporous polymeric gratings can act as biosensing platforms which are label-free, inexpensive, and applicable as high-throughput assays.

Graphical abstract: Aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings: fabrication and application in biosensing

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Article information

DOI
https://doi.org/10.1039/B711200A
Article type
Paper
Submitted
23 Jul 2007
Accepted
28 Sep 2007
First published
12 Oct 2007

J. Mater. Chem., 2007,17, 4896-4901

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Aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings: fabrication and application in biosensing

V. K. S. Hsiao, J. R. Waldeisen, Y. Zheng, P. F. Lloyd, T. J. Bunning and T. J. Huang, J. Mater. Chem., 2007, 17, 4896 DOI: 10.1039/B711200A

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