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Issue 42, 2007
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Polymer microcapsules as mobile local pH-sensors

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Abstract

Polyelectrolyte microcapsules have been loaded with a pH-sensitive, high molecular weight SNARF-1-dextran conjugate. SNARF-1 exhibits a significant pH-dependent emission shift from green to red fluorescence under acidic and basic conditions, respectively. The unique spectral properties of the dye were maintained after the encapsulation. By investigating both human breast cancer cells and fibroblasts, we were able to follow the pH change of the local environment of SNARF-1-filled capsules during the transition from the alkaline cell medium to the acidic endosomal/lysosomal compartments. The incorporation of magnetite nanoparticles and an additional pH-insensitive fluorophore within the capsule shell resulted in a novel type of sensor system based on multifunctional polymer capsules.

Graphical abstract: Polymer microcapsules as mobile local pH-sensors

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Supplementary files

Article information


Submitted
10 Apr 2007
Accepted
22 Jun 2007
First published
12 Jul 2007

J. Mater. Chem., 2007,17, 4471-4476
Article type
Paper

Polymer microcapsules as mobile local pH-sensors

O. Kreft, A. M. Javier, G. B. Sukhorukov and W. J. Parak, J. Mater. Chem., 2007, 17, 4471
DOI: 10.1039/B705419J

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