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Issue 43, 2007
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[(η-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(η-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0–2), and CO2CH2CH2OH: a new group of CO-releasing molecules

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Abstract

A new group of CO-releasing molecules, CO-RMs, based on cyclopentadienyl iron carbonyls have been identified. X-Ray structures have been determined for [(η-C5H4CO2Me)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me, [(η-C5H4CO2Me)Fe(CO)2]2, [(η-C5H4CO2CH2CH2OH)Fe(CO)2]2 and [(η-C5H4CO2Me)Fe(CO)3][FeCl4]. Half-lives for CO release, 1H, 13C, and 17OC NMR and IR spectra have been determined along with some biological data for these compounds, [(η-C5H4CO2CH2CH2OH)Fe(CO)3]+ and [{η-C5H4(CH2)nCO2Me}Fe(CO)3]+, n = 1, 2. More specifically, cytotoxicity assays and inhibition of nitrite formation in stimulated RAW264.7 macrophages are reported for most of the compounds analyzed. [(η-C5H5)Fe(CO)2X], X = Cl, Br, I, were also examined for comparison. Correlations between the half-lives for CO release and spectroscopic parameters are found within each group of compounds, but not between the groups.

Graphical abstract: [(η-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(η-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0–2), and CO2CH2CH2OH: a new group of CO-releasing molecules

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Publication details

The article was received on 30 Mar 2007, accepted on 21 May 2007 and first published on 19 Sep 2007


Article type: Paper
DOI: 10.1039/B704832G
Citation: Dalton Trans., 2007,0, 4962-4973
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    [(η-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(η-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0–2), and CO2CH2CH2OH: a new group of CO-releasing molecules

    D. Scapens, H. Adams, T. R. Johnson, B. E. Mann, P. Sawle, R. Aqil, T. Perrior and R. Motterlini, Dalton Trans., 2007, 0, 4962
    DOI: 10.1039/B704832G

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