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Issue 10, 2007
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Peptidomimetics via copper-catalyzed azide–alkyne cycloadditions

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Abstract

This critical review concerns the impact of copper-mediated alkyneazide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities (e.g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.

Graphical abstract: Peptidomimetics via copper-catalyzed azide–alkyne cycloadditions

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Publication details

The article was received on 15 Mar 2007 and first published on 12 Jun 2007


Article type: Critical Review
DOI: 10.1039/B701444A
Chem. Soc. Rev., 2007,36, 1674-1689

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    Peptidomimetics via copper-catalyzed azide–alkyne cycloadditions

    Y. L. Angell and K. Burgess, Chem. Soc. Rev., 2007, 36, 1674
    DOI: 10.1039/B701444A

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