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Issue 3, 2007
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Synthetic metallomolecules as agents for the control of DNA structure

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Abstract

This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems.

Graphical abstract: Synthetic metallomolecules as agents for the control of DNA structure

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Article information


Submitted
04 Jul 2006
Accepted
13 Sep 2006
First published
17 Oct 2006

Chem. Soc. Rev., 2007,36, 471-483
Article type
Tutorial Review

Synthetic metallomolecules as agents for the control of DNA structure

A. D. Richards and A. Rodger, Chem. Soc. Rev., 2007, 36, 471
DOI: 10.1039/B609495C

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