Chemo-differentiating ABB′ multicomponent reactions. Privileged building blocks
Abstract
Multicomponent reactions (MCRs) designated as ABB′ are defined as those reactions that introduce into the final product one molecule of component A and two molecules of component B in a chemo-differentiating manner. This ability to discriminate the incorporation of component B ensures that these processes maintain the advantages of using multicomponent reactions in diversity-oriented molecular construction. Furthermore, they benefit from the fact that only two reagents need to be mixed together. Component B can be therefore considered to be a privileged building block, and the reactions in which it participates, chemo-differentiating multicomponent reactions. Among the reduced set of compounds capable of acting as such building blocks, we discuss the use of