Issue 4, 2007
From the journal:

Chemical Society Reviews

Release mechanisms for polyelectrolyte capsules

Bruno G. De Geest,a   Niek N. Sanders,a   Gleb B. Sukhorukov,b   Joseph Demeestera  and  Stefaan C. De Smedt*a  

* Corresponding authors

a Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
E-mail: stefaan.desmedt@ugent.be
Fax: +32 9 264 81 89
Tel: +32 9 264 80 76

b Centre for Material Research, Queen Mary College, University of London, Mile End 116, UK E1 4NS London
E-mail: g.sukhorukov@qmul.ac.uk
Fax: +44 20 8981 9804
Tel: +32 20 7882 5508

Abstract

Polyelectrolyte capsules have recently been introduced as new microscopic vehicles which could have high potential in the biomedical field. In this critical review we give an introduction to the layer-by-layer (LbL) technique which is used to fabricate these polyelectrolyte capsules as well as to the different triggers that have been exploited to obtain drug release from these capsules. Furthermore, other types of triggered delivery systems are compared and critically discussed with regard to their clinical relevance. (171 references.)

Graphical abstract: Release mechanisms for polyelectrolyte capsules

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Article information

DOI
https://doi.org/10.1039/B600460C
Article type
Critical Review
Submitted
18 Aug 2006
First published
13 Oct 2006

Chem. Soc. Rev., 2007,36, 636-649

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Release mechanisms for polyelectrolyte capsules

B. G. De Geest, N. N. Sanders, G. B. Sukhorukov, J. Demeester and S. C. De Smedt, Chem. Soc. Rev., 2007, 36, 636 DOI: 10.1039/B600460C

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