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Issue 39, 2007
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Non-covalent interactions in biomacromolecules

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Non-covalent interactions play an important role in chemistry, physics and especially in biodisciplines. They determine the structure of biomacromolecules such as DNA and proteins and are responsible for the molecular recognition process. Theoretical evaluation of interaction energies is difficult; however, perturbation as well as variation (supermolecular) methods are briefly described. Accurate interaction energies can be obtained by complete basis set limit calculations providing a large portion of correlation energy is covered (e.g. by performing CCSD(T) calculations). The role of H-bonding and stacking interactions in the stabilisation of DNA, oligopeptides and proteins is described, and the importance of London dispersion energy is shown.

Graphical abstract: Non-covalent interactions in biomacromolecules

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The article was received on 29 Mar 2007, accepted on 25 May 2007 and first published on 14 Jun 2007

Article type: Perspective
DOI: 10.1039/B704781A
Phys. Chem. Chem. Phys., 2007,9, 5291-5303

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    Non-covalent interactions in biomacromolecules

    J. Černý and P. Hobza, Phys. Chem. Chem. Phys., 2007, 9, 5291
    DOI: 10.1039/B704781A

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