Issue 45, 2007
From the journal:

Chemical Communications

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange†

Stefano Avedano,a   Lorenzo Tei,a   Alberto Lombardi,b   Giovanni B. Giovenzana,b   Silvio Aime,*c   Dario Longoc  and  Mauro Botta*a  

* Corresponding authors

a Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale “Amedeo Avogadro”, Via Bellini 25/G, I-15100 Alessandria, Italy
E-mail: mauro.botta@mfn.unipmn.it

b DiSCAFF & DFB Center, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Via Bovio 6, I-28100 Novara, Italy

c Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy
E-mail: silvio.aime@unito.it

Abstract

Two new GdEGTA (EGTA = ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.

Graphical abstract: Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B714438E
Article type
Communication
Submitted
20 Sep 2007
Accepted
16 Oct 2007
First published
26 Oct 2007

Chem. Commun., 2007, 4726-4728

Permissions

Request permissions

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

S. Avedano, L. Tei, A. Lombardi, G. B. Giovenzana, S. Aime, D. Longo and M. Botta, Chem. Commun., 2007, 4726 DOI: 10.1039/B714438E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements