Issue 36, 2007
From the journal:

Chemical Communications

Linear, redox modified DNA probes as electrochemical DNA sensors†

Francesco Ricci,ac   Rebecca Y. Laiab  and  Kevin W. Plaxco*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, USA

b Department of Physics and Institute for Polymers and Organic Solids, University of California, Santa Barbara, California, USA

c On leave from the University of Rome Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Via della Ricerca Scientifica, Rome, Italy

Abstract

We show here that hybridization-linked changes in the dynamics of a redox-modified, electrode-bound linear (as opposed to stem-loop) probe DNA produce large changes in Faradaic current, allowing for the ready detection of target oligonucleotides.

Graphical abstract: Linear, redox modified DNA probes as electrochemical DNA sensors

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Article information

DOI
https://doi.org/10.1039/B708882E
Article type
Communication
Submitted
15 Jun 2007
Accepted
20 Jun 2007
First published
05 Jul 2007

Chem. Commun., 2007, 3768-3770

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Linear, redox modified DNA probes as electrochemical DNA sensors

F. Ricci, R. Y. Lai and K. W. Plaxco, Chem. Commun., 2007, 3768 DOI: 10.1039/B708882E

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