Issue 34, 2007
From the journal:

Chemical Communications

Amplified electrochemical detection of DNA through the aggregation of Au nanoparticles on electrodes and the incorporation of methylene blue into the DNA-crosslinked structure†

Di Li,a   Yiming Yan,a   Agnieszka Wieckowskaa  and  Itamar Willner*a  

* Corresponding authors

a Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
E-mail: willnea@vms.huji.ac.il
Fax: +972 2 6527715
Tel: +972 2 6585272

Abstract

The amplified electrochemical sensing of DNA is accomplished by the analyte-induced aggregation of nucleic acid-functionalized Au nanoparticles, deposition of the aggregates on a thiolated monolayer-functionalized electrode, and the voltammetric analysis of the redox-active methylene blue intercalated in the nucleic acid duplexes associated with the aggregates.

Graphical abstract: Amplified electrochemical detection of DNA through the aggregation of Au nanoparticles on electrodes and the incorporation of methylene blue into the DNA-crosslinked structure

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Article information

DOI
https://doi.org/10.1039/B704731B
Article type
Communication
Submitted
29 Mar 2007
Accepted
10 Jul 2007
First published
02 Aug 2007

Chem. Commun., 2007, 3544-3546

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Amplified electrochemical detection of DNA through the aggregation of Au nanoparticles on electrodes and the incorporation of methylene blue into the DNA-crosslinked structure

D. Li, Y. Yan, A. Wieckowska and I. Willner, Chem. Commun., 2007, 3544 DOI: 10.1039/B704731B

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