Issue 17, 2007
From the journal:

Chemical Communications

Conformational control of HCl co-transporter: imidazole functionalised isophthalamidevs. 2,6-dicarboxamidopyridine†

Philip A. Gale,*a   Joachim Garric,a   Mark E. Light,a   Beth A. McNallyb  and  Bradley D. Smith*b  

* Corresponding authors

a School of Chemistry, University of Southampton, Southampton, UK
E-mail: philip.gale@soton.ac.uk
Fax: +44 23 8059 6805
Tel: +44 23 8059 3332

b Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA
E-mail: smith.115@nd.edu
Fax: +1 574 631 6652
Tel: +1 574 631 8632

Abstract

Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux.

Graphical abstract: Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine

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Article information

DOI
https://doi.org/10.1039/B703259E
Article type
Communication
Submitted
05 Mar 2007
Accepted
27 Mar 2007
First published
04 Apr 2007

Chem. Commun., 2007, 1736-1738

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Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine

P. A. Gale, J. Garric, M. E. Light, B. A. McNally and B. D. Smith, Chem. Commun., 2007, 1736 DOI: 10.1039/B703259E

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