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Issue 16, 2007

A Ramberg–Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

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Abstract

A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg–Bäcklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg–Bäcklund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties.

Graphical abstract: A Ramberg–Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

Supplementary files

Article information


Submitted
15 Feb 2007
Accepted
09 Mar 2007
First published
20 Mar 2007

Chem. Commun., 2007, 1617-1619
Article type
Communication

A Ramberg–Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

J. E. Robinson and R. J. K. Taylor, Chem. Commun., 2007, 1617 DOI: 10.1039/B702411H

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