Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A

Ian Paterson; Edward A. Anderson; Stephen M. Dalby; Julien Genovino; Jong Ho Lim; Christian Moessner

doi:10.1039/B700827A

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Synthesis of two diastereomeric C₁–C₂₂ fragments of spirastrellolide A†

Ian Paterson,*^a Edward A. Anderson,^a Stephen M. Dalby,^a Julien Genovino,^a Jong Ho Lim^a and Christian Moessner^a

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^a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ip100@cam.ac.uk
Fax: +44 1223 336362
Tel: +44 1223 336407

Abstract

The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C₁–C₂₂ fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.

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Supplementary files

Compounds 5, 7, 3, 4 PDF (449K)

Article information

DOI: https://doi.org/10.1039/B700827A
Article type: Communication
Submitted: 18 Jan 2007
Accepted: 29 Jan 2007
First published: 14 Feb 2007

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Chem. Commun., 2007, 1852-1854

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Synthesis of two diastereomeric C₁–C₂₂ fragments of spirastrellolide A

I. Paterson, E. A. Anderson, S. M. Dalby, J. Genovino, J. H. Lim and C. Moessner, Chem. Commun., 2007, 1852 DOI: 10.1039/B700827A

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