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Issue 20, 2007
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Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

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Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Graphical abstract: Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

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Article information


Submitted
02 Jan 2007
Accepted
17 Jan 2007
First published
22 Feb 2007

Chem. Commun., 2007, 2075-2077
Article type
Communication

Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

F. Kopp, S. Wunderlich and P. Knochel, Chem. Commun., 2007, 2075
DOI: 10.1039/B618923G

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