Issue 20, 2007
From the journal:

Chemical Communications

Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems†

G. Réthoré,a   T. Montier,b   T. Le Gall,b   P. Delépine,b   S. Cammas-Marion,a   L. Lemiègre,a   P. Lehnb  and  T. Benvegnu*a  

* Corresponding authors

a ENSCR, UMR CNRS 6226 Sciences Chimiques de Rennes, “Equipe Synthèse Organique et Systèmes Organisés”, Avenue du Général Leclerc, 35700 Rennes, France
E-mail: thierry.benvegnu@ensc-rennes.fr

b Unité INSERM 613, Institut de Synergie des Sciences et de la Santé, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, Avenue Foch, 29220 Brest, France

Abstract

Novel cationic liposomes, termed “archaeosomes”, based on mixtures of neutral/cationic bilayer-forming lipids and archaeobacterial synthetic tetraether-type bipolar lipids show efficient in vitro gene transfection properties and represent a new approach for modulating the lipidic membrane fluidity of the complexes they form with DNA.

Graphical abstract: Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

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Article information

DOI
https://doi.org/10.1039/B618568A
Article type
Communication
Submitted
20 Dec 2006
Accepted
27 Mar 2007
First published
11 Apr 2007

Chem. Commun., 2007, 2054-2056

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Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

G. Réthoré, T. Montier, T. Le Gall, P. Delépine, S. Cammas-Marion, L. Lemiègre, P. Lehn and T. Benvegnu, Chem. Commun., 2007, 2054 DOI: 10.1039/B618568A

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