Issue 1, 2007
From the journal:

Chemical Communications

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid†

Ian Paterson*a  and  Nicola M. Gardnera  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ip100@cam.ac.uk
Fax: +44 (0)1223 336362
Tel: +44 (0)1223 336407

Abstract

A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition.

Graphical abstract: Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

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Article information

DOI
https://doi.org/10.1039/B615122A
Article type
Communication
Submitted
18 Oct 2006
Accepted
01 Nov 2006
First published
23 Nov 2006

Chem. Commun., 2007, 49-51

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Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

I. Paterson and N. M. Gardner, Chem. Commun., 2007, 49 DOI: 10.1039/B615122A

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