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Abstract | Cited by

Asymmetric desymmetrization of 4-substituted cyclohexanones using proline amide-catalyzed direct aldol reaction afforded β-hydroxyketones with three stereogenic centers in high enantioselectivities of up to >99% ee.

Graphical abstract: Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

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