Direct 23Na NMR observation of mixed cations residing inside a G-quadruplex channel

Ramsey Ida; Irene C. M. Kwan; Gang Wu

doi:10.1039/B613105K

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Direct ²³Na NMR observation of mixed cations residing inside a G-quadruplex channel†

Ramsey Ida,^a Irene C. M. Kwan^a and Gang Wu*^a

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* Corresponding authors

^a Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada
E-mail: gangwu@chem.queensu.ca
Fax: +613 533 6669
Tel: +613 533 2644

Abstract

We report direct ²³Na NMR observation for the presence of mixed cations (Na⁺/K⁺, Na⁺/Rb⁺, Na⁺/Sr²⁺) inside the G-quadruplex channel formed by the self-association of guanosine 5′-monophosphate at pH 8.

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Supplementary files

Plot showing the NMR results from Na/Rb titration experiment and atomic coordinates of the G-quadruplex model used in quantum chemical calculations PDF (322K)

Article information

DOI: https://doi.org/10.1039/B613105K
Article type: Communication
Submitted: 14 Sep 2006
Accepted: 26 Oct 2006
First published: 15 Nov 2006

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Chem. Commun., 2007, 795-797

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Direct ²³Na NMR observation of mixed cations residing inside a G-quadruplex channel

R. Ida, I. C. M. Kwan and G. Wu, Chem. Commun., 2007, 795 DOI: 10.1039/B613105K

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