Issue 21, 2007

Asymmetric organocatalytic reductions mediated by dihydropyridines

Abstract

Catalytic asymmetric reduction reactions have long been the preserve of the transition metal catalyst. Inspired by the myriad efficient enzyme-catalysed reduction reactions routine in biological systems, chemists have recently begun to design chiral metal-free organocatalysts that employ synthetic dihydropyridine NADH analogues as the hydride source with impressive results. Recent developments in this burgeoning field are discussed.

Graphical abstract: Asymmetric organocatalytic reductions mediated by dihydropyridines

Article information

Article type
Perspective
Submitted
27 Jul 2007
First published
11 Sep 2007

Org. Biomol. Chem., 2007,5, 3407-3417

Asymmetric organocatalytic reductions mediated by dihydropyridines

S. J. Connon, Org. Biomol. Chem., 2007, 5, 3407 DOI: 10.1039/B711499K

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