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Issue 21, 2007
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Engineering proteins with tailored nanomechanical properties: a single molecule approach

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Abstract

Elastomeric proteins underlie the elasticity of natural adhesives, cell adhesion and muscle proteins. They also serve as structural materials with superb mechanical properties. Single molecule force spectroscopy has made it possible to directly probe the mechanical properties of elastomeric proteins at the single molecule level and revealed insights into the molecular design principles of elastomeric proteins. Combining single molecule atomic force microscopy and protein engineering techniques, it has become possible to engineer proteins with tailored nanomechanical properties. These efforts are paving the way to design artificial elastomeric proteins with well-defined nanomechanical properties for application in nanomechanics and materials sciences.

Graphical abstract: Engineering proteins with tailored nanomechanical properties: a single molecule approach

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Publication details

The article was received on 06 Jul 2007, accepted on 06 Aug 2007 and first published on 21 Sep 2007


Article type: Emerging Area
DOI: 10.1039/B710321M
Org. Biomol. Chem., 2007,5, 3399-3406

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    Engineering proteins with tailored nanomechanical properties: a single molecule approach

    H. Li, Org. Biomol. Chem., 2007, 5, 3399
    DOI: 10.1039/B710321M

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