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Issue 16, 2007
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Maturation of McjA precursor peptide into active microcin MccJ25

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Abstract

Microcin J25 is a ribosomally synthesised 21-residue antimicrobial peptide produced by certain strains of enterobacteria, that adopts an extraordinary ‘threaded lasso’ structure. To date, the biosynthesis of this peptide is little understood. Here we report the in vitro maturation of the microcin precursor peptide into active microcin J25 for the first time. Furthermore, we show that the enzymes required for the posttranslational modification of this precursor peptide are associated with the bacterial inner membrane.

Graphical abstract: Maturation of McjA precursor peptide into active microcin MccJ25

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Publication details

The article was received on 05 Jun 2007, accepted on 27 Jun 2007 and first published on 11 Jul 2007


Article type: Communication
DOI: 10.1039/B708478A
Org. Biomol. Chem., 2007,5, 2564-2566

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    Maturation of McjA precursor peptide into active microcin MccJ25

    D. J. Clarke and D. J. Campopiano, Org. Biomol. Chem., 2007, 5, 2564
    DOI: 10.1039/B708478A

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