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Issue 1, 2007
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Synthesis of protein–polymer conjugates

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Abstract

Protein–polymer conjugates are widely employed for applications in medicine, biotechnology and nanotechnology. Covalent attachment of synthetic polymers to proteins improves protein stability, solubility, and biocompatibility. Furthermore, synthetic polymers impart new properties such as self assembly and phase behavior. Polymer attachment at amino acid side-chains and at ligand binding sites is typically exploited. This Emerging Area focuses on synthetic methods to prepare protein-reactive polymers and also employing the protein itself as an initiator for polymerization.

Graphical abstract: Synthesis of protein–polymer conjugates

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Article information


Submitted
29 Aug 2006
Accepted
12 Oct 2006
First published
08 Nov 2006

Org. Biomol. Chem., 2007,5, 45-53
Article type
Emerging Area

Synthesis of protein–polymer conjugates

K. L. Heredia and H. D. Maynard, Org. Biomol. Chem., 2007, 5, 45
DOI: 10.1039/B612355D

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