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Issue 14, 2007
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A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

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Abstract

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS–NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

Graphical abstract: A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

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Publication details

The article was received on 23 May 2007, accepted on 11 Jun 2007 and first published on 18 Jun 2007


Article type: Communication
DOI: 10.1039/B707762A
Org. Biomol. Chem., 2007,5, 2211-2213

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    A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

    N. Brendel, L. P. Partida-Martinez, K. Scherlach and C. Hertweck, Org. Biomol. Chem., 2007, 5, 2211
    DOI: 10.1039/B707762A

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