Issue 14, 2007

A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

Abstract

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS–NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

Graphical abstract: A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2007
Accepted
11 Jun 2007
First published
18 Jun 2007

Org. Biomol. Chem., 2007,5, 2211-2213

A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

N. Brendel, L. P. Partida-Martinez, K. Scherlach and C. Hertweck, Org. Biomol. Chem., 2007, 5, 2211 DOI: 10.1039/B707762A

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