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Issue 6, 2007
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Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines

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Abstract

There is a growing need in organic synthesis for efficient methodologies for the asymmetric synthesis of quaternary carbon centres. One of the most attractive and straightforward methods focuses on the use of asymmetric catalysis for the addition of various types of nucleophiles on prochiral ketones and ketimines. A view of the literature from this growing area of research will be presented in this review, with an emphasis on the pioneer works and milestones brought by the main players in this field.

Graphical abstract: Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines

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Publication details

The article was received on 05 Dec 2006 and first published on 05 Feb 2007


Article type: Perspective
DOI: 10.1039/B617746H
Org. Biomol. Chem., 2007,5, 873-888

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    Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines

    O. Riant and J. Hannedouche, Org. Biomol. Chem., 2007, 5, 873
    DOI: 10.1039/B617746H

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